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Bernard Hirschel | Charge virale indétectable | Contamination et prévention | Couples concernés par le VIH

Patients treated for HIV, with undetectable viremia, are no longer infectious: arguments for and against

16 January 2008 (papamamanbebe.net)

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Footnotes

[1] Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group [see comments]. N Engl J Med 2000;342(13):921-9.

[2] Bernard Hirschel: «Avec les trithérapies, nous avons les moyens théoriques d’éradiquer le sida».

[3] Vernazza PL, Troiani L, Flepp MJ, Cone RW, Schock J, Roth F et al. Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. AIDS 2000;14(2):117-21.

[4] Cu-Uvin S, Caliendo AM, Reinert S, Chang A, Juliano-Remollino C, Flanigan TP et al. Effect of highly active antiretroviral therapy on cervicovaginal HIV-1 RNA. AIDS 2000;14(4):415-21.

[5] Cu-Uvin S, Snyder B, Harwell JI, Hogan J, Chibwesha C, Hanley D et al. Association between paired plasma and cervicovaginal lavage fluid HIV-1 RNA levels during 36 months. J.Acquir.Immune.Defic.Syndr. 2006;42(5):584-7.

[6] Taylor S, Sadiq ST, Weller I, Kaye S, Workman J, Cane PA et al. Drug-resistant HIV-1 in the semen of men receiving antiretroviral therapy with acute sexually transmitted infections. Antivir.Ther. 2003;8(5):479-83.

[7] Sadiq ST, Taylor S, Kaye S, Bennett J, Johnstone R, Byrne P et al. The effects of antiretroviral therapy on HIV-1 RNA loads in seminal plasma in HIV-positive patients with and without urethritis. AIDS 2002;16(2):219-25.

[8] Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group [see comments]. N Engl J Med 2000;342(13):921-9.

[9] Katz MH, Gerberding JL. Postexposure treatment of people exposed to the human immunodeficiency virus through sexual contact or injection-drug use. N.Engl.J.Med. 1997;336(15):1097-100.

[10] Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group [see comments]. N Engl J Med 2000;342(13):921-9.

[11] Zuckerman RA, Whittington WL, Celum CL, Collis TK, Lucchetti AJ, Sanchez JL et al. Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy. J.Infect.Dis. 2004;190(1):156-61.

[12] Lampinen TM, Critchlow CW, Kuypers JM, Hurt CS, Nelson PJ, Hawes SE et al. Association of antiretroviral therapy with detection of HIV-1 RNA and DNA in the anorectal mucosa of homosexual men. AIDS 2000;14(5):F69-F75.

[13] Zuckerman RA, Whittington WL, Celum CL, Collis TK, Lucchetti AJ, Sanchez JL et al. Higher concentration of HIV RNA in rectal mucosa secretions than in blood and seminal plasma, among men who have sex with men, independent of antiretroviral therapy. J.Infect.Dis. 2004;190(1):156-61.

[14] Barroso PF, Schechter M, Gupta P, Melo MF, Vieira M, Murta FC et al. Effect of antiretroviral therapy on HIV shedding in semen. Ann.Intern.Med. 2000;133(4):280-4.

[15] Jin F, Prestage GP, Ellard J, Kippax SC, Kaldor JM, Grulich AE. How homosexual men believe they became infected with HIV: the role of risk-reduction behaviors. J.Acquir.Immune.Defic.Syndr. 2007;46(2):245-7.

[16] Castilla J, Del Romero J, Hernando V, Marincovich B, Garcia S, Rodriguez C. Effectiveness of highly active antiretroviral therapy in reducing heterosexual transmission of HIV. J.Acquir.Immune.Defic.Syndr. 2005;40(1):96-101.

[17] Garcia PM, Kalish LA, Pitt J, Minkoff H, Quinn TC, Burchett SK et al. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group. N.Engl.J.Med. 1999;341(6):394-402.

[18] Béclère, A., De Wolf, F., Boerlijst, M. C., van Sighem, A., Hollingsworth, D., Prins, M., Geskus, R., Gras, L, Coutinho, R., and Fraser, C. Despite HAART, HIV-1 is once agin spreading among MSM in the Netherlands. 14th Conference on retroviruses and Opportunistic Infections, Los Angeles, California , Paper # 151. 1-2-2007.